David Crumrine
	Title:	Professor, Physical Organic Chemistry
	Phone:	(773) 508-3114
	E-mail:	dcrumri@luc.edu

Personal Information

A.B., 1966, Ashland College
Ph.D., 1971, University of Wisconsin, Madison
Postdoctoral, 1971-72, Massachussetts Institute of Technology/Georgia Tech.
Visiting Scholar Institute of Molecular Science, 1980 Okazaki, Japan.
Visiting Scholar, 1981, Oxford University.
Visiting Lecturer, Summer 1988, University of Chicago

Research Interests

Using methylene blue dye derivatives, as singlet oxygen generators, attached to peptides and proteins continues to be interesting. Initial work on neuropeptides showed efficient singlet oxygen production and good binding. Calcitonin was also attached and studiedWe are now working with cross-linked hemoglobins aiming toward a selective new technique for photodynamic therapy.

Collaborative work on gramicidin dimers has been very productive! Working with a physiologist and a theoretician, we have begun to better understanding ion transport in this novel peptide system. We are synthesizing a new series of dimers to expand our work.

All of this can be viewed as mechanistic studies. We also work on remote effects on addition reactions and the use of 33S 17O, 23Na, and 6Li NMR to probe solvation, pKa, substituent, and counterion effects in sulfonate acids, salts, and buffers. 33S and 17O NMR are sensitive to pH effects. A substituent changes the state of protonation in aromatic sulfonic acids and various buffers such as HEPES.

Selected Publications

"Receptor Inactivation by Dye-Neuropeptide Conjugates: 2. Characterization of the Quantum Yield of Singlet Oxygen Generated by Irridation of Dye-Neuropeptide Conjugates" J.J. Feigenbaum, M.D.Choubal, D.S. Crumrine, and J.R. Kanofsky, Peptides, 1996, 17, 1213-1217.

"Receptor Inactivation by Dye-Neuropeptide Conjugates: 3. Comparative Binding of Dye-Neuropeptide Conjugates to FMRFamide Receptors of Helix aspersa and Loligo pealei", J.J. Feigenbaum, M.D. Choubal, D.S. Crumrine, J.R. Kanofsky, K. Payza, Peptides, 1996, 17,1279-1284.

"The Conduction of Protons in Gramicidin A and its Dioxolane-linked Dimer in Different Lipid Bilayers", S. Cukierman, E. P. Quigley, and D. S. Crumrine. Biophys. J., 1997, 73, 2489-2502.

Long range aryl migration and electrocyclic ring opening (LRAMERO), M. Peeran and D.S. Crumrine, Trends in Organic Chemistry, 1997, 6, 45.

"Proton Current Attenuation by Methanol in a Dioxolane-linked Gramicidin A Channel in Different Lipid Bilayers", E. P. Quigley, A. J. Emerick, D. S. Crumrine, and S. Cukierman. Biophys. J., 1998, 75, 2811-2820.

"The Conduction of Protons in Different Stereoisomers of Dioxolane-linked Gramicidin A Channels", E.P.Quigley, P. Quigley, D.S.Crumrine, and S. Cukierman, Biophys. J., 1999, 77, 2479-2491.

"Gating and Permeation in Ion Channels formed by Gramicidin A and its Dioxolane-linked Dimer in Na+& Cs+ solutions" E. P. Quigley, D. S. Crumrine and S. Cukierman, J. Memb. Bio., 2000, 174, 207-212.

"Covalently Linked Gramicidin Channels: Effects of Linker Hydrophobicity and Alkaline Metals on Different Stereoisomers" K. M. Armstrong, E. P. Quigley, D. S. Crumrine, S. Cukierman, Biophys. J., 2001, 80, 1810-1818.

"Proton Transfer in Water Wires in Proteins: Modulation by Local Constraint and polarity in Gramidin A Channels" S. Narayan, D.L. Wyatt, D.S. Crumrine, S. Cukierman, Biophys. J., 2007, 93, 1571-1579.