Loyola University Chicago

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Loyola University Chicago

Department of Chemistry and Biochemistry

Holz, Richard

Title: Professor & Associate Dean
Resources and Planning 
Office: FH 420
Phone: (773) 508-3092
E-mail: rholz1@luc.edu 


Personal Information



The Holz research group interfaces the general areas of mechanistic enzymology and biophysical chemistry but recently, our interests have also moved into biomolecular nanotechnology. In general the Holz group is interested in structure/function studies of metalloenzymes, which includes the design, synthesis, and characterization of small molecules that function as potent inhibitors. Within these studies, we use a wide variety of biophysical methods such as enzyme kinetics, site-directed mutagenesis, isothermal titration calorimetry, UV-Vis, NMR and EPR spectroscopies. We have integrated our work on metalloenzymes with biomaterials by investigating nano to micro-sized biologically powered motors as well as biomolecule recognition at surfaces. Devises of this type have many potential applications but clearly offer new technologies for the design of molecular detection devices.



National Science Foundation - (CHE-0652981) 03/1/06 -02/28/09  "Mechanistic Studies on Dinuclear Metallohydrolases that are Novel Antibacterial Targets" The long range goals of this research are to elucidate the roles of each metal ion is catalysis for the aminopeptidase from Aeromonas proteolytica and the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae (dapE).  Using a mechanism based approach a new class of antibiotics that target dapE will be designed and synthesized.



Department of Chemistry & Biochemistry
Loyola University Chicago · 1032 W. Sheridan Rd., Chicago, IL 60660
Phone: 773.508.3100 · Fax: 773.508.3086

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